China (Mainland)
ABT737 CAS NO.852808-04-9
- Min.Order: 1 Metric Ton
- Payment Terms: T/T,
- Product Details
Keywords
- ABT737
- ABT-737
- 852808-04-9
Quick Details
- ProName: ABT737
- CasNo: 852808-04-9
- Appearance: white powder
- DeliveryTime: within 3 days after payment
- PackAge: 25kg/drum
- Port: Shanghai, Shenzhen, Guangzhou, Hongkon...
- ProductionCapacity: 1 Metric Ton/Day
- Purity: >98%
- Storage: Kept in a cool, dry and ventilated pla...
- LimitNum: 1 Metric Ton
- Moisture Content: <0.5%
- Impurity: <0.2%
Superiority
| Product Name:ABT737 |
| Synonyms:ABT-737 |
| Cas No.:852808-04-9 |
| Molecular Formula:C42H45ClN6O5S2 |
| Molecular Weight:813.43 |
| Purity:98% |
| Apperarnce:yellow solid |
A selective inhibitor of BCL-2, in small cell lung cancer. ABT-737 induced dramatic regressions in tumors derived from some SCLC cell lines. In vitro, peripheral blood CLL cells are extremely sensitive to ABT-737 (EC50 ~7 nM).
The Bcl-2 antagonist ABT-737 targets Bcl-2/Bcl-xL ,ABT-737 induces Bax conformational change but fails to activate Bak or trigger Bax translocation. Coadministration of roscovitine and ABT-737 untethers Bak from Mcl-1 and Bcl-xL, respectively, triggering Bak activation and Bax translocation
Details
| Product Name:ABT737 |
| Synonyms:ABT-737 |
| Cas No.:852808-04-9 |
| Molecular Formula:C42H45ClN6O5S2 |
| Molecular Weight:813.43 |
| Purity:98% |
| Apperarnce:yellow solid |
A selective inhibitor of BCL-2, in small cell lung cancer. ABT-737 induced dramatic regressions in tumors derived from some SCLC cell lines. In vitro, peripheral blood CLL cells are extremely sensitive to ABT-737 (EC50 ~7 nM).
The Bcl-2 antagonist ABT-737 targets Bcl-2/Bcl-xL ,ABT-737 induces Bax conformational change but fails to activate Bak or trigger Bax translocation. Coadministration of roscovitine and ABT-737 untethers Bak from Mcl-1 and Bcl-xL, respectively, triggering Bak activation and Bax translocation