China (Mainland)
17AAG CAS NO.75747-14-7
- Min.Order: 1 Metric Ton
- Payment Terms: T/T,
- Product Details
Keywords
- 17AAG
- Tanespimycin
- 75747-14-7
Quick Details
- ProName: 17AAG
- CasNo: 75747-14-7
- Appearance: white powder
- DeliveryTime: 3 days after payment
- PackAge: 25kg/drum
- Port: Shanghai,Shenzhen,Guangzhou,HongKong
- ProductionCapacity: 1 Metric Ton/Day
- Purity: >99%
- Storage: Keep in cool and dry place, away from ...
- LimitNum: 1 Metric Ton
- Moisture Content: <0.5%
- Impurity: total <1.0%
Superiority
| Product Name:17AAG;Tanespimycin |
| Synonyms:NSC330507;CP 127374 |
| Cas No.:75747-14-7 |
|
M.Wt: 585.69 Formula: C31H43N3O8 Solubility: Soluble in DMSO or Methanol. Clear Purple solution at 10mg/ml Purity: >99% Storage: Storage at -20℃ 2 years |
Details
| Product Name:17AAG;Tanespimycin |
| Synonyms:NSC330507;CP 127374 |
| Cas No.:75747-14-7 |
|
M.Wt: 585.69 Formula: C31H43N3O8 Solubility: Soluble in DMSO or Methanol. Clear Purple solution at 10mg/ml Purity: >99% Storage: Storage at -20℃ 2 years |
17AAG is a less toxic analogue of the geldanamycin which binds to Hsp90 (Heat Shock Protein 90) and alters it function. Hsp90 plays a key role in regulating the physiology of cells exposed to environmental stress and in maintaining the malignant phenotype of tumor cells. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, and oncogenesis. 17-AAG binds with a high affinity into the ATP binding pocket in Hsp90 and induces the degradation of proteins that require this chaperone for conformational maturation.