China (Mainland)
Barasertib CAS NO.722544-51-6
- Min.Order: 1 Metric Ton
- Payment Terms: T/T,
- Product Details
Keywords
- AZD1152
- Barasertib
- 722544-51-6
Quick Details
- ProName: Barasertib
- CasNo: 722544-51-6
- Appearance: white powder
- DeliveryTime: 3 days after payment
- PackAge: 25kg/drum
- Port: Shanghai,Shenzhen,Guangzhou,HongKong
- ProductionCapacity: 1 Metric Ton/Day
- Purity: >99%
- Storage: Keep in cool and dry place, away from ...
- LimitNum: 1 Metric Ton
- Moisture Content: <0.5%
- Impurity: total <1.0%
Superiority
| Product Name:AZD1152-HQPA(Barasertib) |
| Cas No.:722544-51-6 |
|
M.Wt: 507.56 Formula: C26H30FN7O3 Solubility: DMSO Purity: >99% Storage: -20℃ 2 years |
Details
| Product Name:AZD1152-HQPA(Barasertib) |
| Cas No.:722544-51-6 |
|
M.Wt: 507.56 Formula: C26H30FN7O3 Solubility: DMSO Purity: >99% Storage: -20℃ 2 years |
AZD1152 is a dihydrogen phosphate prodrug of a pyrazoloquinazoline Aurora kinase inhibitor [AZD1152?Chydroxyquinazoline pyrazol anilide (HQPA)] and is converted rapidly to the active AZD1152-HQPA in plasma . AZD1152-HQPA is a highly potent and selective inhibitor of Aurora B (Ki, 0.36 nM) compared with Aurora A (Ki, 1,369 nM) and has a high specificity versus a panel of 50 other kinases. Consistent with inhibition of Aurora B kinase, addition of AZD1152-HQPA to tumor cells in vitro induces chromosome misalignment, prevents cell division, and consequently reduces cell viability and induces apoptosis.