SULBUTIAMINE CAS NO.3286-46-2

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Sulbutiamine, chemically isobutyryl thiamine disulfide,  is a fat soluble vitamin B1 derivative that was developed in Japan to treat vitamin B1 deficiency beriberi. Sulbutiamine is superior to thiamine, regular vitamin b1, as it crosses the blood brain barrier with ease, probably due to its lipophilicity.

Sulbutiamine is used off label for the  treatment of asthenia and fatigue that is of non muscular origin, i.e. perceived fatigue in the brain. Early rodent studies also suggest sulbutiamine can prevent drug induced memory deficits and improve object recognition.

As a nootropic, sulbutiamine is frequently taken on a short term basis to enhance motivation, strengthen memory and support mood. It appears with frequent use a tolerance can develop, so this nootropic is probably best used sparingly.

Other names:

Isobutyrl thiamine disulfide, Arcalion (brand name), Enerion (brand name).