China (Mainland)
ABT-869 CAS NO.796967-16-3
- Min.Order: 1 Metric Ton
- Payment Terms: T/T,
- Product Details
Keywords
- ABT-869
- Linifanib
- 796967-16-3
Quick Details
- ProName: ABT-869
- CasNo: 796967-16-3
- Appearance: white powder
- DeliveryTime: within 3 days after payment
- PackAge: 25kg/drum
- Port: Shanghai, Shenzhen, Guangzhou, Hongkon...
- ProductionCapacity: 1 Metric Ton/Day
- Purity: >98%
- Storage: Kept in a cool, dry and ventilated pla...
- LimitNum: 1 Metric Ton
Superiority
| Product Name:ABT-869(Linifanib) |
| Synonyms:AL-39324,RG3635,ABT869 |
| Cas No.:796967-16-3 |
| Molecular Formula:C21H18FN5O |
| Molecular Weight:375.41 |
| Purity:98% |
| Apperarnce:white powder |
Details
| Product Name:ABT-869(Linifanib) |
| Synonyms:AL-39324,RG3635,ABT869 |
| Cas No.:796967-16-3 |
| Molecular Formula:C21H18FN5O |
| Molecular Weight:375.41 |
| Purity:98% |
| Apperarnce:white powder |
ABT-869 is multi-targeted in that it is a potent inhibitor of all members of the VEGF and PDGF receptor families (e.g., KDR IC50 value of 4 nM), but has much less activity (IC50 values >1 nM) against unrelated receptor tyrosine kinases, soluble tyrosine kinases or serine/threonine kinases. The kinase inhibition profile of ABT-869 is evident in cellular assays of RTK phosphorylation (IC50 values of 2, 4 and 7 nM for PDGFR, KDR and CSF-1R, respectively) and VEGF-stimulated proliferation (0.2 nM IC50 for human endothelial cells).