WZ4003

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Min.Order: 1 Gram
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WZ4003

ProName: WZ4003
Appearance: white powder
Application: for laboratory research
DeliveryTime: within 3 days after payment
PackAge: Aluminium foil bag packing
Port: Shanghai, Shenzhen, Guangzhou, Hongkon...
ProductionCapacity: 1 Kilogram/Day
Purity: >99%
Storage: Kept in a cool, dry and ventilated pla...
Transportation: by air; by sea; by express
LimitNum: 1 Gram
Heavy metal: <0.002%
Grade: Industrial Grade

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Molecular Weight (MW)	496.99
Formula	C₂₅H₂₉ClN₆O₃
CAS No.	1214265-58-3
Synonyms	N/A

Solubility (25°C)


Storage	2 years -20℃Powder
Storage	6 months-80℃in DMSO

Chemical Name	Propanamide, N-?[3-?[[5-?chloro-?2-?[[2-?methoxy-?4-?(4-?methyl-?1-?piperazinyl)?phenyl]?amino]?-?4-?pyrimidinyl]?oxy]?phenyl]?-

Description

WZ4003 is a highly specific NUAK kinase inhibitor with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively, without significant inhibition on 139 other kinases.

In HEK-293 cells expressing wild-type NUAK1, WZ4003 (3–10 μM) markedly suppresses NUAK1-mediated MYPT1 phosphorylation. Moreover, WZ4003 (10 μM) inhibits MYPT1 Ser445 phosphorylation as well as cell migration, invasion and proliferation to a similar extent as knock out in MEFs or knock down in U2OS cells of NUAK1. ^[1] WZ4003 also exhibits a high, specific affinity to the L858R/T790M mutant EGFR, while a significantly reduced cellular IC50 against T790M containing Ba/F3 cells. ^[2]